A STRUCTURALLY CONSERVED SITE IN AUP1 BINDS THE E2 ENZYME UBE2G2 AND IS ESSENTIAL FOR ER-ASSOCIATED DEGRADATION.

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.

Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis.Although multiple Sensor Cable ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination.Here, we characterize a key role for the UBE2G2 Binding Region (G

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Cultural Adaptation of 2 Evidence-Based Alcohol Interventions for Antiretroviral Treatment Clinic Patients in Vietnam

In Vietnam where alcohol use is culturally normative and little treatment is available, persons living with HIV (PLWH) who consume alcohol at unhealthy levels are at greatly increased risk for negative health outcomes.We describe the SAM-E 400MG first systematic adaptation of 2 evidence-based alcohol interventions for use in Vietnam: a combined mot

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The Effect of Solvents on the Crystal Morphology of Pyriproxyfen

To obtain crystal products with ideal morphology and better quality, it is important to fully understand and grasp the affecting mechanism of solvents on crystal morphology.In this work, the interactions between solvent/solute molecules and different crystal faces of pyriproxyfen are investigated No Chew Spray by a combination of experiments and mo

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Antimicrobial Activity of Selected Banana Cultivars Against Important Human Pathogens, Including Candida Biofilm

Ten banana (Musa spp.) cultivars were studied for their antimicrobial properties.Three plant parts (corm, Socks pseudostem and leaves) were collected separately and extracted with different solvents, viz., hexane, acetone, ethanol and water.The 50% inhibitory concentration (IC50) was evaluated using a broth microdilution assay.Eight human bacterial

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Assessing socio-economic vulnerability to climate change-induced disasters: evidence from Sundarban Biosphere Reserve, India

Indian Sundarban SAM-E 400MG Biosphere Reserve (SBR), a fragile ecosystem, is susceptible to frequent cyclones, floods, and storm surge.The study impeccably analyzed the socio-economic vulnerability in SBR using pragmatic approach.Average storm surge height, slope amount, flood inundation, drainage proximity, and drainage density were used for asse

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